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Functional versus Structural Deficit

Meaning

Functional versus Structural Deficit is a clinical distinction used to categorize the nature of a physiological impairment within the endocrine system or other body systems. A functional deficit implies an issue with the process or activity of an organ or pathway, such as impaired hormone signaling or reduced enzyme activity, without a change in physical structure. Conversely, a structural deficit refers to a demonstrable physical abnormality or damage to the organ’s form, such as glandular atrophy or tissue fibrosis. This differentiation is crucial for determining the appropriate therapeutic intervention and prognosis.