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Functional Somatostatin Blockade

Meaning

Functional Somatostatin Blockade is a therapeutic concept involving the strategic inhibition of somatostatin’s biological activity to achieve a desired physiological outcome, typically the enhancement of Growth Hormone (GH) secretion. Somatostatin, a naturally occurring peptide, acts as a potent inhibitor of GH release from the pituitary gland. By temporarily or partially blocking its inhibitory action, clinicians can leverage the body’s natural pulsatile GH release, promoting anabolic effects and tissue repair. This intervention is designed to mimic the reduced somatostatin tone observed in younger, healthier states.