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Functional Hypothyroidism Reversal

Meaning

Functional Hypothyroidism Reversal refers to the clinical strategy aimed at restoring optimal thyroid hormone function at the cellular level, even when standard serum thyroid-stimulating hormone (TSH) and free T4 levels appear to be within normal laboratory reference ranges. This condition, often termed euthyroid sick syndrome or non-thyroidal illness, involves impaired peripheral conversion of T4 to the active T3, or reduced T3 receptor sensitivity. Reversal focuses on addressing the underlying systemic stressors, such as chronic inflammation or nutritional deficiencies, that inhibit T3 action.