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Functional Hypogonadism Reversibility

Meaning

Functional hypogonadism reversibility refers to the potential for fully restoring normal function of the gonadal axis and endogenous sex hormone production in cases of functional hypogonadism. This specific form of hypogonadism is often secondary to reversible physiological stressors like chronic energy deficit, intense psychological stress, or severe acute illness, characterized by suppressed hypothalamic-pituitary signaling without primary gonadal failure. The concept of reversibility offers a therapeutic pathway toward endogenous hormone recovery, often negating the need for permanent hormone replacement therapy.