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Functional Hypogonadism Mechanism

Meaning

Functional Hypogonadism Mechanism describes the specific physiological pathways leading to suppressed gonadal function—reduced testosterone or estrogen production—that are not caused by primary testicular or ovarian failure or a structural pituitary disorder. This form of hypogonadism is often reversible, resulting from systemic stressors like chronic illness, excessive exercise, severe calorie restriction, or psychological distress, which primarily inhibit the central hypothalamic-pituitary control. It represents a state of adaptive suppression where the reproductive axis is temporarily downregulated to conserve energy for survival. Understanding this mechanism guides treatment toward addressing the underlying systemic stressor.