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Functional Hypogonadism Markers

Meaning

Functional Hypogonadism Markers are a set of specific biochemical and clinical indicators that collectively point toward a state of secondary or functional hypogonadism, where the gonads are capable of producing hormones but are inhibited by external factors or central regulatory dysfunction, rather than primary organ failure. These markers typically include low-normal or suppressed gonadotropins, such as Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), alongside low-normal or frankly low sex steroids like Testosterone or Estradiol. Identifying these markers helps differentiate treatable, lifestyle-induced hormonal suppression from irreversible primary gonadal disease.