A clinical objective focused on achieving the highest possible efficiency and appropriate pulsatility of endogenous hormone production and action across all major regulatory axes, including sex hormones, thyroid, and cortisol. This moves beyond simply normalizing lab values to optimizing physiological performance.
Origin
This strategy synthesizes endocrinology with functional medicine principles, emphasizing the dynamic interplay between hormones rather than isolated concentrations. Optimization implies maximizing therapeutic benefit while minimizing adverse effects.
Mechanism
Achieving this involves precise assessment of receptor dynamics, precursor availability, and clearance rates of steroid and peptide hormones. Interventions are tailored to improve the entire feedback loop, ensuring target tissues receive the correct signal strength at the correct time.
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