What is the Origin of Functional Hormonal Resistance?

This concept evolved from clinical observations where standard hormone assays did not correlate with expected physiological outcomes, pointing toward issues downstream of ligand-receptor binding. It separates deficiency from functional inefficacy at the cellular level.

What is the Mechanism of Functional Hormonal Resistance?

Resistance mechanisms often involve alterations in intracellular signaling cascades, such as reduced phosphorylation of downstream substrates or receptor downregulation due to chronic ligand exposure. For instance, chronic inflammation can induce kinases that interfere with normal receptor tyrosine kinase activity. Correcting this requires addressing the underlying inflammatory or metabolic drivers causing the post-receptor blockade.

Functional Hormonal Resistance ∞ Area

Functional Hormonal Resistance

Meaning

Functional Hormonal Resistance describes a state where target tissues exhibit a diminished or blunted cellular response to circulating hormone levels that are otherwise considered adequate or even elevated. This condition reflects post-receptor impairment rather than absolute hormone deficiency. It is a common finding in metabolic syndrome affecting insulin and androgen signaling.