A comprehensive, patient-centered clinical assessment that evaluates the entire endocrine system’s functional capacity and its interconnectedness with other physiological systems, moving beyond standard disease diagnosis. This review utilizes advanced diagnostic testing to identify subtle hormonal imbalances, suboptimal ranges, and underlying causes of dysfunction, such as chronic stress or nutritional deficits. The goal is to restore optimal hormonal signaling and homeostatic balance for enhanced well-being.
Origin
This approach stems from the principles of Functional Medicine, which originated in the late 20th century, combined with classical endocrinology. The “Functional” aspect signifies a focus on the optimal performance of biological systems rather than just the absence of pathology.
Mechanism
The review operates by mapping hormonal feedback loops, including the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes, and assessing hormone metabolism and clearance pathways. By analyzing precursors, active hormones, and metabolites, the clinician can pinpoint where the cascade is breaking down. Intervention is then targeted to support the body’s intrinsic mechanisms for hormone synthesis and receptor sensitivity.
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