Functional Age Determination is a clinical process that quantifies an individual’s biological age—the actual physiological and cellular condition—as distinct from their chronological age. This determination is based on a panel of objective, measurable biomarkers that reflect the integrity and performance of various organ systems and fundamental biological processes. The result provides a tangible metric for assessing the effectiveness of longevity and wellness interventions.
Origin
This concept is central to the emerging field of geroscience and longevity medicine, which seeks to measure and intervene in the fundamental mechanisms of aging. It stems from the observation that individuals of the same chronological age exhibit significant variability in healthspan and disease risk. The term signifies a paradigm shift towards assessing biological function over mere time elapsed.
Mechanism
Determination relies on analyzing specific biomarkers, often including epigenetic clocks (like DNA methylation patterns), telomere length, physiological reserve tests, and metabolic health indicators. These markers collectively reflect the cumulative damage from cellular senescence, oxidative stress, and chronic inflammation. The underlying mechanism is the translation of molecular and physiological data into a single, actionable metric of systemic health and vitality.
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