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Fuel Source Switching

Meaning

Fuel Source Switching, also known as metabolic flexibility, is the physiological capacity of the body to seamlessly and efficiently transition between utilizing glucose (carbohydrates) and fatty acids (fats) as its primary energy substrate in response to changes in nutrient availability or energy demand. This dynamic adaptability is a hallmark of robust metabolic health and is closely regulated by the actions of insulin and glucagon. Impaired fuel source switching is a clinical indicator of insulin resistance and metabolic dysfunction. The ability to switch fuels efficiently is vital for maintaining cellular energy balance.