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Fuel Partitioning Dynamics

Meaning

Fuel Partitioning Dynamics describes the intricate, hormonally-regulated process by which the body determines the fate of ingested macronutrients, specifically deciding whether to direct glucose, fatty acids, and amino acids toward immediate oxidation for energy, storage as glycogen or adipose tissue, or utilization for tissue repair and synthesis. This dynamic process is heavily influenced by key endocrine signals like insulin, glucagon, cortisol, and growth hormone. Optimal partitioning is critical for maintaining lean body mass, preventing insulin resistance, and supporting metabolic flexibility. Dysfunction in these dynamics is a hallmark of metabolic aging and chronic disease.