What is the Origin of FSH?

The term is an acronym for Follicle-Stimulating Hormone, named for its primary physiological action observed upon its discovery in the early 20th century. It belongs to the system of pituitary hormones, which are named based on their target organs and stimulating functions. Its discovery was a cornerstone in understanding reproductive endocrinology.

What is the Mechanism of FSH?

FSH exerts its biological effect by binding to specific G-protein coupled receptors (FSHR) located on the surface of granulosa cells in the ovary and Sertoli cells in the testes. This receptor binding activates an intracellular signaling cascade, primarily involving the adenylyl cyclase pathway, leading to an increase in cyclic AMP (cAMP). The resulting rise in cAMP concentration drives the transcription of genes necessary for follicular development, steroidogenesis, and the production of sperm.

FSH

Meaning

Follicle-Stimulating Hormone, a critical gonadotropin glycoprotein secreted by the anterior pituitary gland that plays a fundamental role in regulating reproductive function in both males and females. In women, FSH stimulates the growth and maturation of ovarian follicles and promotes estrogen production. In men, it is essential for stimulating spermatogenesis in the Sertoli cells of the testes. Clinical measurement of FSH levels is a standard diagnostic tool for assessing fertility, ovarian reserve, and hypothalamic-pituitary-gonadal axis function.

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FSH

Meaning

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