What is the Origin of FSH Suppression?

The term combines the hormone abbreviation (FSH) with "suppression," meaning to forcibly put an end to or subdue. Its context in endocrinology relates directly to the principle of negative feedback within the HPG axis, where elevated levels of gonadal steroids inhibit gonadotropin release. This is a fundamental mechanism of hormonal control.

What is the Mechanism of FSH Suppression?

Exogenous administration of androgens or estrogens provides negative feedback to the hypothalamus and pituitary, leading to decreased pulsatile release of GnRH and subsequent reduction in FSH synthesis and secretion. In clinical scenarios, this mechanism is exploited therapeutically, though it can also result as an unintended consequence of certain treatments, leading to iatrogenic hypogonadism. The reduction in FSH effectively halts the stimulation required for gamete maturation.

FSH Suppression ∞ Area

FSH Suppression

Meaning

FSH Suppression is the clinical observation where the secretion of Follicle-Stimulating Hormone (FSH) from the anterior pituitary gland is actively reduced below normal physiological ranges. This inhibition directly impacts gonadal function, as FSH is crucial for spermatogenesis in males and follicular development in females. We monitor this effect when administering exogenous hormones or investigating central endocrine disorders.

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How Do GnRH Antagonists Compare to GnRH Agonists in Clinical Practice?

GnRH antagonists offer immediate hormonal suppression by directly blocking pituitary receptors, while agonists induce a delayed shutdown via initial overstimulation.

∞ Testosterone Flare
∞ GnRH Antagonists
∞ GnRH Agonists

HRTioJuly 28, 2025

FSH Suppression

Meaning

Origin

Mechanism

How Do GnRH Antagonists Compare to GnRH Agonists in Clinical Practice?

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