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FSH Receptor Polymorphism

Meaning

FSH Receptor Polymorphism refers to the occurrence of different genetic variations, or alleles, in the gene that codes for the Follicle-Stimulating Hormone (FSH) receptor protein, primarily found on ovarian granulosa cells and testicular Sertoli cells. These specific single-nucleotide polymorphisms (SNPs) can alter the receptor’s structure, thereby influencing its binding affinity for FSH and the efficiency of the subsequent intracellular signaling cascade. Clinically, these polymorphisms are significant because they can affect a woman’s ovarian response to endogenous FSH or to exogenous gonadotropin therapy used in fertility treatments. Understanding a patient’s genetic profile in this receptor is a step toward truly personalized reproductive endocrinology.