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Frontostriatal Circuits

Meaning

Frontostriatal circuits are dense, reciprocal neural pathways connecting the frontal lobes of the cerebral cortex, particularly the prefrontal cortex, with the striatum in the basal ganglia. These critical loops are integral to motor control, habit formation, goal-directed behavior, reward processing, and executive function. Dysregulation within these circuits is implicated in various neurological and psychiatric conditions, and their function is highly sensitive to the modulating effects of neurohormones.