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Free Testosterone Titration

Meaning

Free Testosterone Titration is the precise clinical process of systematically adjusting exogenous or endogenous hormonal therapies to achieve an optimal serum concentration of free (unbound) testosterone. This specific measurement is considered the most physiologically relevant indicator of androgen status, as it represents the biologically active fraction of the hormone available to bind to cellular receptors. Accurate titration is paramount for maximizing therapeutic benefits, ensuring optimal androgen effect, and effectively mitigating potential side effects.