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Free Testosterone Restoration

Meaning

Free Testosterone Restoration is a clinical objective focused on increasing the biologically active, unbound fraction of testosterone in the circulation to optimal physiological levels. Free testosterone, which is not bound to Sex Hormone-Binding Globulin (SHBG) or albumin, is the fraction that can readily diffuse into target tissues and activate the androgen receptor. Strategies for restoration move beyond simply raising total testosterone and focus specifically on modulating SHBG levels and optimizing the overall hormonal milieu to enhance bioavailable androgen action. Achieving optimal free testosterone is critical for male and female health, supporting muscle mass, bone density, mood, and libido.