A calculated ratio or direct measurement used in endocrinology to estimate the concentration of unbound, biologically active testosterone available to interact with androgen receptors in target tissues.
Origin
This methodology arose from the clinical need to accurately assess androgen status, as total testosterone levels can be misleading due to variable Sex Hormone-Binding Globulin (SHBG) concentrations.
Mechanism
Indexing typically involves calculating the fraction of free testosterone based on total testosterone and SHBG levels, or employing equilibrium dialysis, providing a more relevant metric for assessing androgenicity.
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