Free Testosterone Bioavailability

Meaning

Free testosterone bioavailability is the fraction of total circulating testosterone that is unbound to any plasma proteins, specifically Sex Hormone-Binding Globulin (SHBG) and albumin, making it immediately available to diffuse into target cells and exert its biological effects. This unbound portion represents the biologically active fraction of the hormone, directly correlating with androgenic activity in tissues such as muscle, bone, and the central nervous system. Clinically, measuring free testosterone provides a more accurate assessment of a patient’s functional hormonal status compared to total testosterone alone, especially when SHBG levels are abnormal.

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