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Free Testosterone Analysis

Meaning

Free testosterone analysis is a specialized clinical measurement that quantifies the fraction of circulating testosterone not bound to carrier proteins, primarily Sex Hormone-Binding Globulin (SHBG) and albumin. This unbound fraction, known as free testosterone, is the biologically active component capable of diffusing into cells and binding to androgen receptors to exert its physiological effects. The free level is a far more accurate indicator of androgen status and tissue bioavailability than total testosterone alone, especially in cases of altered SHBG levels.