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Free T Bioavailability Mapping

Meaning

Free T bioavailability mapping is a sophisticated diagnostic process that goes beyond a simple measurement of total or free testosterone to precisely characterize the fraction of the hormone that is unbound and biologically active at the cellular level. This mapping assesses the dynamic interplay between total testosterone and key carrier proteins, such as sex hormone-binding globulin (SHBG) and albumin, which directly influence the hormone’s availability to target tissues. By calculating the free androgen index and often employing equilibrium dialysis or mass spectrometry, clinicians gain a precise understanding of the patient’s true androgenic status. This detailed physiological context is essential for accurate diagnosis and precision dosing in hormone replacement therapy.