Free Radical Scavenging Capacity represents the collective efficiency of endogenous enzymatic systems and exogenous dietary compounds to neutralize reactive oxygen species (ROS) within tissues. A high capacity is essential for mitigating oxidative stress, which is a known driver of cellular damage and accelerated aging. We assess this to gauge the system’s defense against molecular instability.
Origin
Originating in biochemistry, this term relates directly to the study of redox biology and the impact of unpaired electrons on cellular macromolecules. In hormonal health, it is linked to lipid peroxidation, which can impair steroid hormone synthesis.
Mechanism
The capacity functions through direct neutralization, where antioxidants like glutathione or Vitamin E donate electrons to quench ROS, stabilizing them before they can damage lipids, proteins, or DNA. Enzymatic scavengers such as Superoxide Dismutase (SOD) and Catalase catalyze the conversion of highly reactive species into less harmful byproducts, thus protecting cellular structures integral to endocrine function.
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