Free Radical Elimination refers to the biochemical processes by which the body neutralizes reactive oxygen species (ROS) that cause oxidative stress and cellular damage to lipids, proteins, and DNA. This process is essential for preserving cellular integrity and supporting optimal endocrine function, as excessive oxidation can impair hormone synthesis and receptor function. It is a critical defense mechanism against molecular decay.
Origin
The term is derived from biochemistry and molecular biology, specifically the study of oxidative stress, a process intrinsically linked to aging and chronic disease pathogenesis. Its importance in hormonal health is recognized through the impact of oxidative damage on steroidogenic tissues.
Mechanism
Elimination occurs primarily through the action of endogenous antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, which convert highly reactive species into stable, inert molecules. Supplementation with specific cofactors can enhance the efficiency of these enzymatic pathways. Successfully managing this balance supports membrane fluidity and the necessary electron transport chain activity for ATP generation.
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