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Free Hormone Hypothesis Validation

Meaning

Free hormone hypothesis validation is the clinical and scientific confirmation that the concentration of the unbound, or “free,” fraction of a hormone in the circulation is the most accurate predictor of its biological activity and the clinical status of the patient. This validation supports the paradigm that total hormone levels alone are often insufficient for diagnosis and therapeutic monitoring, especially in conditions where carrier proteins are dysregulated. It is the cornerstone of precision endocrinology.