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Free Fatty Acid Feedback

Meaning

Free Fatty Acid Feedback describes the regulatory loop where the concentration of non-esterified fatty acids (NEFAs) circulating in the bloodstream directly influences metabolic processes, particularly glucose and insulin homeostasis. Elevated levels of NEFAs, often resulting from excessive lipolysis in adipose tissue, can signal a state of energy surplus or cellular stress. This signal subsequently leads to peripheral insulin resistance in both muscle and liver tissues, representing a critical component of metabolic syndrome and type 2 diabetes pathology.