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Frailty Indices

Meaning

Frailty Indices are quantitative, composite clinical metrics used to measure an individual’s accumulated deficits across multiple physiological systems, serving as a robust predictor of vulnerability to adverse health outcomes, morbidity, and mortality. These indices integrate diverse factors, including physical capacity, cognitive function, nutritional status, and chronic disease burden, providing a holistic assessment of biological resilience. A high Frailty Index score indicates a reduced physiological reserve and an increased susceptibility to stressors, making it a critical biomarker in longevity medicine. Monitoring these indices helps guide interventions aimed at preserving functional independence and extending healthspan.