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FRα-binding Peptides

Meaning

FRα-binding Peptides are a class of synthetic or naturally derived short-chain amino acids specifically engineered to bind with high affinity to the Folate Receptor alpha (FRα) protein. The Folate Receptor alpha is a glycosylphosphatidylinositol-anchored protein often overexpressed on the surface of various malignant cells, including certain ovarian and lung cancers, while expression is typically low in healthy tissues. These peptides are designed to act as targeting moieties, delivering therapeutic payloads like imaging agents or cytotoxic drugs directly to the FRα-expressing cells. Their development represents a significant advance in targeted drug delivery systems.