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FoxP3

Meaning

FoxP3, or Forkhead Box P3, is a crucial transcription factor protein whose expression is considered the master regulator and defining marker of regulatory T cells (Tregs) within the immune system. Tregs are a specialized subset of lymphocytes responsible for maintaining immunological self-tolerance, preventing autoimmune reactions, and modulating the overall inflammatory response. The precise regulation of FoxP3 expression is vital for preventing the immune system from mistakenly attacking the body’s own tissues, a process particularly relevant in endocrine autoimmunity.