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FOXO4-DRI

Meaning

FOXO4-DRI is a synthetic peptide specifically engineered to disrupt the inhibitory interaction between the transcription factor FOXO4 and the critical tumor suppressor protein p53. The acronym stands for Forkhead Box O4 – D-Retro-Inverso peptide, referencing its modified molecular structure. This specific disruption is a critical, key mechanism in selectively inducing apoptosis, or programmed cell death, exclusively within senescent cells. It represents a leading example of a senolytic agent currently under investigation for its potential to functionally reverse specific aspects of age-related tissue dysfunction.