Skip to main content

FOXO3A

Meaning

FOXO3A, or Forkhead Box O3A, is a transcription factor encoded by the FOXO3 gene that is a highly conserved, master regulator of cellular stress resistance, metabolism, and DNA repair pathways. In the domain of hormonal health and longevity, FOXO3A is considered one of the most compelling genetic markers for human longevity, with specific allelic variants consistently associated with exceptional old age in diverse populations. It functions as a critical node linking the insulin/IGF-1 signaling pathway to cellular defense mechanisms.