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FOXA1

Meaning

FOXA1, or Forkhead Box A1, is a crucial pioneering transcription factor protein that plays a pivotal, foundational role in chromatin remodeling and the establishment of an accessible chromatin landscape for various nuclear receptors. It is a key member of the Forkhead box family of proteins, functioning as a master regulator of gene expression in numerous tissues, including the mammary glands and prostate. In the context of hormonal health, FOXA1 is recognized as a key determinant of the cellular response and specificity to both estrogen and androgen signaling pathways.