What is the Origin of Foundational Hormones?

This classification originates from clinical endocrinology, grouping hormones based on their broad systemic influence and their shared biosynthetic pathway from cholesterol precursors. They are considered foundational because deviations significantly impact multiple organ systems simultaneously.

What is the Mechanism of Foundational Hormones?

The mechanism of action involves binding to specific intracellular or nuclear receptors, thereby modulating gene expression related to protein synthesis, lipolysis, and inflammation control. Proper foundational hormone levels ensure that anabolic processes dominate over catabolic ones, supporting structural advantage and metabolic efficiency. Their appropriate interplay is key to achieving an Optimal Biological State.

Foundational Hormones

Meaning

Foundational Hormones are the core group of steroid and peptide signaling molecules—including testosterone, estrogen, progesterone, DHEA, and cortisol—that serve as primary regulators for numerous downstream physiological processes. These compounds are essential precursors or direct mediators for maintaining muscle mass regulation, bone density, and central nervous system function. Their appropriate levels dictate the overall anabolic potential of the organism.