Question 1

What is the Meaning of Foreign Body Granuloma?

Accepted Answer

A foreign body granuloma is a specific, localized form of chronic inflammation that develops as a nodular cluster of immune cells surrounding non-biodegradable material introduced into the body. This pathological structure represents the body's defensive attempt to wall off and contain an inert, persistent foreign substance, such as remnants of injectable fillers, suture material, or certain implanted hormone pellets. In the wellness domain, it is a potential complication following cosmetic or therapeutic implantation procedures.

Question 2

What is the Origin of Foreign Body Granuloma?

Accepted Answer

The term is rooted in pathology and immunology, where "foreign body" denotes the exogenous, non-self material and "granuloma" describes the characteristic microscopic organization of the inflammatory response. This reaction is a fundamental mechanism of the innate immune system against materials it cannot eliminate through typical phagocytosis. Understanding the etiology is crucial for both prevention and management of complications arising from various implantable or injectable medical and aesthetic devices.

Question 3

What is the Mechanism of Foreign Body Granuloma?

Accepted Answer

The process begins when macrophages attempt to engulf the foreign material but fail due to its size or chemical nature. These frustrated macrophages then fuse to form multinucleated giant cells, which are the hallmark of this reaction. These giant cells and surrounding immune cells, including lymphocytes and fibroblasts, organize into a dense, encapsulated structure of granulation tissue, thereby sequestering the substance from the rest of the body to mitigate further systemic exposure or local tissue damage.

Foreign Body Granuloma

Meaning

Origin

Mechanism

Can Contaminated Injections Alter the Effectiveness of Hormone Replacement Therapy?

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