What is the Origin of Follicle-Stimulating Hormone Suppression?

This process is intrinsically linked to the function of the hypothalamic-pituitary-gonadal (HPG) axis, the primary endocrine system governing reproductive and sexual development. FSH is one of the two key gonadotropins released by the pituitary, acting on the gonads to stimulate gamete production. The concept of suppression is based on the HPG axis's inherent negative feedback loop mechanism.

What is the Mechanism of Follicle-Stimulating Hormone Suppression?

Suppression is typically achieved by administering exogenous sex steroids, such as testosterone or estradiol, which elevate circulating hormone levels. These elevated levels signal back to the hypothalamus and pituitary, inhibiting the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) and subsequently suppressing the pituitary's secretion of FSH. This negative feedback loop is a fundamental regulatory process within the endocrine system.

Follicle-Stimulating Hormone Suppression ∞ Area

Follicle-Stimulating Hormone Suppression

Meaning

Follicle-Stimulating Hormone Suppression refers to the clinical strategy of deliberately reducing the secretion of Follicle-Stimulating Hormone (FSH) from the anterior pituitary gland. This suppression is a common objective in hormonal health protocols, particularly when managing conditions like excess testosterone administration or certain reproductive disorders. Effective suppression requires careful monitoring to maintain the overall integrity of the hypothalamic-pituitary-gonadal axis.