Skip to main content

FNDC5/Irisin

Meaning

FNDC5/Irisin refers to a coupled biological system where FNDC5 (Fibronectin type III domain containing 5) is the transmembrane precursor protein, and Irisin is the resulting myokine, a hormone-like peptide released into circulation primarily following muscular contraction. Irisin functions as an endocrine messenger, mediating the systemic benefits of exercise, particularly its role in energy metabolism and thermogenesis. It represents a significant link between the musculoskeletal system and metabolic health.