Skip to main content

First Hour Pharmacology

Meaning

First Hour Pharmacology refers to the highly specific clinical strategy of timing the administration of particular nutritional supplements, necessary medications, or hormonal agents within the initial 60 minutes of waking to purposefully leverage the body’s natural, powerful circadian hormonal shifts. This precise chronobiological timing is utilized to potentiate the therapeutic effect of the agent by aligning its peak concentration with the optimal, physiologically receptive state. The ultimate goal is to maximize bioavailability and synchronize the intervention with the robust, endogenous release of wake-promoting hormones like cortisol.