Question 1

What is the Meaning of FINGER Study?

Accepted Answer

The FINGER Study, an acronym for the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, is a landmark randomized controlled trial demonstrating that a comprehensive, multi-domain lifestyle intervention can protect cognitive function in older adults who are at risk for dementia. The study's profound clinical implication for longevity and wellness is its evidence that cognitive decline is not an inevitable consequence of aging but can be actively mitigated through modifiable lifestyle factors. This work established a paradigm shift from single-target pharmaceutical interventions to holistic, multi-factor precision prevention strategies.

Question 2

What is the Origin of FINGER Study?

Accepted Answer

The study originated in Finland in 2009, led by Professor Miia Kivipelto, to scientifically test the hypothesis that addressing multiple risk factors simultaneously would be more effective than targeting individual factors like diet or exercise alone. It was designed as a gold-standard randomized trial to provide the highest level of evidence for lifestyle-based dementia prevention. Its success led to the formation of the World-Wide FINGERS network, establishing a global model for subsequent multi-domain intervention trials aimed at extending healthspan.

Question 3

What is the Mechanism of FINGER Study?

Accepted Answer

The intervention operates through a synergistic, multi-domain approach that simultaneously targets four key pillars of health: personalized nutritional guidance, structured physical exercise, regular cognitive training, and intensive management of cardiovascular and metabolic risk factors. The biological mechanism involves improving cerebral blood flow, reducing systemic inflammation and oxidative stress, and enhancing brain plasticity and cognitive reserve. By optimizing metabolic and vascular health, the FINGER model indirectly supports neuroendocrine function and protects the brain from the hormonal and vascular damage associated with age-related decline.

FINGER Study

Meaning

Origin

Mechanism

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