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Fibrosis Attenuation

Meaning

Fibrosis Attenuation is the clinical and biological strategy aimed at reducing the progression, severity, or pathological accumulation of excessive fibrous connective tissue, primarily collagen, within a specific organ or tissue. This process of fibrosis represents a failed or maladaptive attempt at tissue repair and invariably leads to organ stiffness, severely impaired functional capacity, and eventual organ failure, which is a common, final pathway in biological aging and chronic disease. Therapeutic attenuation seeks to actively restore a more normal tissue architecture and functional capacity by limiting the overproduction and deposition of extracellular matrix proteins.