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Fibroblast Activation Signaling

Meaning

Fibroblast Activation Signaling describes the biochemical cascade that stimulates dermal fibroblasts, the primary cells of the dermis, to proliferate, migrate, and increase their production of key extracellular matrix components like collagen, elastin, and glycosaminoglycans. This signaling is essential for tissue repair, wound healing, and maintaining the structural density and resilience of the skin. Optimal activation is a hallmark of youthful tissue regeneration. The intensity of this signaling diminishes with age and hormonal decline.