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Fibrinogen

Meaning

Fibrinogen, also known as coagulation factor I, is a large, soluble glycoprotein synthesized by the liver that circulates in the plasma and is central to the final common pathway of the coagulation cascade. Its primary biological function is to be converted into insoluble fibrin strands, which polymerize to form the stable structural meshwork of a blood clot, effectively sealing vascular injuries. Beyond its role in hemostasis, fibrinogen also functions as an acute-phase reactant, meaning its concentration can be elevated in states of systemic inflammation or tissue damage. Clinically, abnormal levels are associated with both bleeding disorders and increased thrombotic risk.