The systemic physiological and hormonal alterations induced by the addition of soluble or insoluble dietary fibers beyond standard dietary intake. This effect primarily manifests in the gastrointestinal tract but exerts profound influence on metabolic and endocrine health. It is a targeted nutritional intervention used to modulate gut microbiome composition and improve glucose and lipid homeostasis.
Origin
This concept stems from nutritional science and gastroenterology, where ‘fiber’ refers to indigestible plant matter and ‘supplementation’ denotes its intentional clinical use. The recognition of its ‘effect’ on the endocrine system is a modern development linking gut health to systemic hormonal regulation. This approach is fundamental to managing metabolic syndrome and dysbiosis.
Mechanism
Soluble fiber is fermented by colonic bacteria, producing short-chain fatty acids (SCFAs) like butyrate, which serve as signaling molecules. These SCFAs enhance intestinal barrier function and stimulate the release of gut hormones, such as GLP-1 and PYY, which improve satiety and insulin sensitivity. Furthermore, fiber binds to bile acids in the intestine, promoting their excretion and indirectly lowering circulating cholesterol levels and modulating estrogen detoxification pathways.
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