Fiber Fermentation Products are biologically active metabolites generated when colonic microbiota anaerobically digest undigested dietary fibers, primarily non-starch polysaccharides. The most clinically relevant products are short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate. These metabolites serve as essential energy sources for colonocytes and act as critical signaling molecules throughout the body.
Origin
This terminology is rooted in nutritional biochemistry and microbial metabolism, describing the end result of the symbiotic process occurring in the large intestine. The ‘fermentation’ process is ancient, while the understanding of these ‘products’ as systemic health modulators is a relatively modern scientific realization. This area bridges dietary intake with gut health and endocrine function.
Mechanism
Once produced, SCFAs are rapidly absorbed and act via G-protein coupled receptors (GPCRs) on various cell types, including enteroendocrine cells and adipocytes. Butyrate is vital for colon health and gut barrier integrity, while propionate and acetate influence glucose and lipid metabolism in the liver and periphery. These fermentation products directly link dietary fiber intake to improved metabolic homeostasis and reduced systemic inflammation.
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