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FFAR3

Meaning

FFAR3, which stands for Free Fatty Acid Receptor 3, is a G protein-coupled receptor primarily activated by short-chain fatty acids (SCFAs), which are metabolites produced by the gut microbiota. This receptor acts as a critical link between the gut environment, metabolic health, and endocrine signaling pathways. It is strategically expressed in various tissues, including the gut, adipose tissue, and pancreatic beta cells, where it plays a role in energy homeostasis and hormone secretion. This receptor is a key mediator of the gut-brain-endocrine axis.