What is the Origin of Female Androgen Deficiency Syndrome?

The concept of FADS arose from the recognition that androgens, primarily testosterone and DHEA, are crucial hormones in women, not just men, and that their decline with age or medical intervention correlates with specific symptom patterns. The term was proposed to provide a framework for discussing and researching the impact of androgen insufficiency in the female endocrine system. It reflects an evolving understanding of hormonal balance and the importance of all sex steroids for female health and quality of life.

What is the Mechanism of Female Androgen Deficiency Syndrome?

The mechanism involves the inadequate production or action of androgens, predominantly testosterone and DHEA, which normally exert effects on the central nervous system, muscle, bone, and sexual tissues. Androgens act through the androgen receptor to modulate mood, energy levels, and sexual function, while also contributing to bone and muscle mass maintenance. Low levels are thought to impair these functions, leading to the characteristic symptoms, underscoring the necessity of a balanced endocrine environment.

Female Androgen Deficiency Syndrome ∞ Area

Female Androgen Deficiency Syndrome

Meaning

Female Androgen Deficiency Syndrome (FADS) is a clinical term describing a constellation of non-specific symptoms, such as persistent unexplained fatigue, decreased libido, reduced sense of well-being, and diminished bone density, occurring in women with measurably low circulating androgen levels. This syndrome is not universally accepted as a distinct diagnostic entity by all medical societies but represents a recognized clinical challenge, often emerging after oophorectomy or during the menopausal transition. Clinical evaluation requires careful exclusion of other endocrine or psychological causes before considering androgen replacement therapy.