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Feedback Loop Reassertion

Meaning

Feedback Loop Reassertion describes the clinical and physiological process of restoring the appropriate sensitivity and functional responsiveness of a dysregulated neuroendocrine feedback loop, such as the Hypothalamic-Pituitary-Adrenal (HPA) or Hypothalamic-Pituitary-Gonadal (HPG) axis. This involves actively correcting the underlying stressors or nutrient deficiencies that caused the initial blunting or exaggerated signaling. Successful reassertion is marked by the return of physiological hormone pulsatility and appropriate negative feedback sensitivity.