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Feedback Loop Precision Loss

Meaning

Feedback Loop Precision Loss refers to the gradual deterioration of the accuracy and timeliness with which the body’s homeostatic systems, particularly the endocrine axes, monitor and correct deviations in hormone concentrations. This loss manifests as increased variability, inappropriate pulsatility, or dampened sensitivity within the control mechanisms of the hypothalamic-pituitary-target gland axis. Diminished precision compromises the fine-tuning necessary for optimal physiological function, often preceding overt hormonal deficiency or excess. This age-associated decline in regulatory control contributes significantly to systemic dyshomeostasis and reduced resilience.