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Feedback Loop Calibration

Meaning

Feedback Loop Calibration refers to the precise clinical adjustment of the intricate, self-regulating circuits within the endocrine system that maintain hormonal homeostasis, such as the Hypothalamic-Pituitary-Adrenal (HPA) axis or the thyroid axis. This involves ensuring that the signaling molecules—hormones—are correctly sensed by their target glands and that the subsequent release or suppression of other hormones occurs with optimal sensitivity and timing. Effective calibration is essential for maintaining the body’s internal stability and resilience against stressors.