Question 1

What is the Meaning of FDG-PET?

Accepted Answer

FDG-PET is a functional medical imaging technique that combines the use of a radiolabeled glucose analog, Fluorodeoxyglucose (FDG), with Positron Emission Tomography (PET) scanning. This diagnostic tool generates a detailed, three-dimensional map of metabolic activity throughout the body by quantifying the uptake of FDG, which is a reliable proxy for cellular glucose utilization. In endocrinology, it is a powerful method for localizing hormonally active tumors, assessing metabolic disease, and evaluating brain glucose consumption.

Question 2

What is the Origin of FDG-PET?

Accepted Answer

The technology is an integration of nuclear medicine and biochemical principles, with "FDG" referring to the tracer, a modified sugar, and "PET" referring to the imaging modality that detects radiation from the tracer. The technique is based on the biological principle that metabolically active cells exhibit increased glucose consumption. Its clinical utility is particularly high in the endocrine domain where many pathologies, such as thyroid cancer or pituitary adenomas, are characterized by altered glucose metabolism.

Question 3

What is the Mechanism of FDG-PET?

Accepted Answer

After intravenous administration, FDG is transported into cells via glucose transporters and is subsequently phosphorylated by hexokinase, a key glycolytic enzyme. Crucially, the resulting FDG-6-phosphate cannot be further metabolized and is effectively trapped inside the cell. The PET scanner detects the gamma rays emitted during the decay of the fluorine-18 radionuclide, allowing for the precise localization and quantification of areas with high glucose metabolic flux, thereby providing functional information about the tissue.

FDG-PET

Meaning

Origin

Mechanism

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