Question 1

What is the Meaning of FDG-PET?

Accepted Answer

FDG-PET, or Fluorodeoxyglucose Positron Emission Tomography, is a functional imaging technique visualizing and quantifying glucose metabolic activity. This diagnostic tool uses a radioactive glucose analog, FDG, to detect areas exhibiting elevated cellular energy demands, often corresponding to disease, providing insight into physiological function.

Question 2

What is the Context of FDG-PET?

Accepted Answer

Within medical diagnostics, FDG-PET provides insight into cellular metabolism. Its utility spans organ systems where abnormal glucose utilization signifies pathology. This imaging modality complements anatomical scans, offering a physiological map highlighting metabolic aberrancy.

Question 3

What is the Significance of FDG-PET?

Accepted Answer

The clinical importance of FDG-PET is substantial, particularly in oncology for cancer detection, staging, and monitoring. This scan provides critical information influencing treatment planning and prognostication, aiding differentiation between benign and malignant lesions. It assesses treatment response, guiding therapies and improving patient outcomes.

Question 4

What is the Mechanism of FDG-PET?

Accepted Answer

FDG-PET's principle relies on preferential uptake of injected FDG by metabolically active cells. Administered intravenously, FDG mimics glucose, entering cells via transporters; after phosphorylation, it becomes trapped. The fluorine-18 isotope decays, emitting positrons interacting with electrons, producing gamma rays detected by the scanner, which reconstructs metabolic hotspot images.

Question 5

What is the Application of FDG-PET?

Accepted Answer

Clinically, FDG-PET involves intravenous tracer administration following patient fasting. After an hour for distribution, the patient undergoes scanning, often integrated with CT for anatomical correlation. This combined PET/CT is routinely used for initial cancer diagnosis, assessing disease extent, detecting metastases, and evaluating therapy effectiveness.

Question 6

What is the Metric of FDG-PET?

Accepted Answer

Quantification of FDG-PET findings commonly uses the Standardized Uptake Value (SUV), a semi-quantitative measure reflecting FDG concentration. SUV values are normalized to injected dose and patient body weight, allowing standardized comparison. Higher SUV values correlate with increased glucose metabolism; clinical interpretation includes qualitative visual assessment. Changes in SUV over sequential scans indicate therapeutic response.

Question 7

What is the Risk of FDG-PET?

Accepted Answer

Potential risks include radiation exposure from the radiotracer and CT. Allergic reactions to FDG are rare. Diabetic patients require careful blood glucose management, as elevated glucose inhibits FDG uptake. False positives can occur from inflammation or physiological uptake; false negatives are possible in low-metabolic tumors. Pregnancy is a contraindication due to fetal radiation.

FDG-PET

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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