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Fatty Acid Synthase Regulation

Meaning

Fatty acid synthase (FAS) regulation refers to the complex transcriptional, post-transcriptional, and allosteric control mechanisms that govern the activity of the Fatty Acid Synthase enzyme, a large multi-enzyme complex responsible for the de novo synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. Precise regulation of FAS is crucial for cellular lipid production, energy storage, and membrane biogenesis. Dysregulation is often observed in metabolic syndrome and certain cancers, reflecting an imbalance in energy homeostasis.